• 國立台灣大學生理學研究所博士

• 馬偕醫醫學院 博士後研究

• 生理學

• 表觀遺傳、神經內分泌

1. Yeh CM, Lai CY, Peng HY, Lin TB, Chou D, Wang HH, Yang PS, Cheng JK, Peng YC, Hsieh MC*.  Protein Arginine Methyltransferase 5 Contributes to Paclitaxel-Induced Neuropathic Pain by Activating Transient Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal Root Ganglion. ANESTHESIA AND ANALGESIA. Vol.138(5):1107-1119. May. 2024. (SCI/SCIE)
2. Li Z, Lee CS, Chen S, He B, Chen X, Peng HY, Lin TB, Hsieh MC, Lai CY, Chou D.  Blue light at night produces stress-evoked heightened aggression by enhancing brain-derived neurotrophic factor in the basolateral amygdala. Neurobiology of Stress. Vol.28:e100600. Jan. 2024. (SCI/SCIE)
3. Hsieh MC, Lai CY, Lin LT, Chou D,  Yeh CM, Cheng JK, Wang HH, Lin KH, Lin TB, Peng HY.  Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons. ACS Chemical Neuroscience. Vol.14(23):4227-4239. Dec. 2023. (SCI/SCIE)
4. Hsieh MC, Lai CY, Cho WL, Lin LT, Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST,  Lin TB, Peng HY.  Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain. ANESTHESIA AND ANALGESIA. Vol.137(6):1289-1301. Dec. 2023. (SCI/SCIE)
5. Lau HH, Lai CY, Hsieh MC,  Peng HY, Chou D, Su TH, Lee JJ,  Lin TB.  Pressure-Volume Loop Analysis of Voiding Workload: An Application in Trans-Vaginal Mesh-Repaired Pelvic Organ Prolapse Patients. BioengineeringBioengineering-Basel. Vol.10(7):853-853. Jul. 2023. (SCI/SCIE)
6. Li Z, Xu Y, Li R, Sheng Z, Chen X, Liu X, Lee CS, Peng HY, Lin TB, Hsieh MC, Lai CY, Wu HF, Chou D.  BTRX-246040 acts through the ventrolateral periaqueductal gray to exert antidepressant-relevant actions in mice. International Journal of Neuropsychopharmacology. Vol.26-No.7:483-495. Jul. 2023. (SCI/SCIE)
7. Hsieh MC , Lai CY , Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST, Lin TB, Peng HY.  Phosphorylated upstream frameshift 1-dependent nonsense-mediated μ opioid receptor mRNA decay in the spinal cord contributes to the development of neuropathic allodynia-like behavior in rats. ANESTHESIOLOGY. Vol.138:634-655. Jun. 2023. (SCI/SCIE)
8. Xu Y, Yu Z, Chen S, Li Z, Long X, Chen M, Lee CS, Peng HY, Lin TB, Hsieh MC, Lai CY, Chou D.  (2R,6R)-hydroxynorketamine targeting the basolateral amygdala regulates fear memory. NEUROPHARMACOLOGY. Vol.225:e109402. Mar. 2023. (SCI/SCIE)
9. Lau HH, Lai CY, Peng HY, Hsieh MC, Su TH, Lee JJ, Lin TB.  Modification of bladder thermodynamics in stress urinary incontinence patients submitted to trans-obturator tape: A retrospective study based on urodynamic assessment. Frontiers in bioengineering and biotechnology. Vol.10:e912602. Aug. 2022. (SCI/SCIE)
10. Lai CY, Hsieh MC, Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST, Lin TB, Peng HY.  MicroRNA-489-3p attenuates neuropathic allodynia by regulating oncoprotein DEK/TET1-dependent epigenetic modification in the dorsal horn. NEUROPHARMACOLOGY. Vol.210:e109028. Jun. 2022. (SCI/SCIE)
11. Peng HY, Lai CY, Hsieh MC, Lin TB.  Solifenacin/Mirabegron Induces an Acute Compliance Increase in the Filling Phase of the Capacity-Reduced Urinary Bladder: A Pressure-Volume Analysis in Rats. Frontiers in Pharmacology. Vol.12:e657959. May. 2021. (SCI/SCIE)
12. MC Hsieh, YC Ho, CY Lai, HH Wang, PS Yang, JK Cheng, GD Chen, SC Ng, AS Lee, KW Tseng, TB Lin, HY Peng.  Blocking the Spinal Fbxo3/CARM1/K + Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief. Neurotherapeutics. Vol.18-No.2:1295-1315. Apr. 2021. (SCI/SCIE)
13. Yang PS, Peng HY, Lin TB, Hsieh MC, Lai CY, Lee AS, Wang HH, Ho YC.  NMDA receptor partial agonist GLYX-13 alleviates chronic stress-induced depression-like behavior through enhancement of AMPA receptor function in the periaqueductal gray. NEUROPHARMACOLOGY. Vol.178:10826-10826. Nov. 2020. (SCI/SCIE)
14. Lin TB, Lai CY, Hsieh MC, Ho YC, Wang HH, Yang PS, Cheng JK, Chen GD, Ng SC, Peng HY.  Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia by attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription. PAIN. Vol.161(9):1995-2009. Sep. 2020. (SCI/SCIE)
15. Peng HY, Lai CY, Hsieh MC, Ho YC, Lin TB.  Pressure-volume analysis of rat's micturition cycles in vivo.. NEUROUROLOGY AND URODYNAMICS. Vol.39(5):1304-1312. Apr. 2020. (SCI/SCIE)
16. Hsieh MC, Peng HY, Ho YC,  Lai CY, Cheng JK, Chen GD, Lin TB.  Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.20(17):1-21. Aug. 2019. (SCI/SCIE)
17. Lai CY, Hsieh MC, Ho YC, Wang HH, Chou D, Wen YC, Cheng JK, Peng HY.  Spinal RNF20-Mediated Histone H2B Monoubiquitylation Regulates mGluR5 Transcription for Neuropathic Allodynia. JOURNAL OF NEUROSCIENCE. Vol.38(43):9160-9174. Oct. 2018. (SCI/SCIE)
18. Chou D, Peng HY, Lin TB, Lai CY, Hsieh MC, Wen YC, Lee AS, Wang HH, Yang PS, Chen GD, Ho YC.  (2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. NEUROPHARMACOLOGY. Vol.139:1-12. Sep. 2018. (SCI/SCIE)
19. Hsieh MC, Ho YC, Lai CY, Chou D, Chen GD, Lin TB, Peng HY.  Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats. Cell Death & Disease. Vol.9(8):811-811. Jul. 2018. (SCI/SCIE)
20. Lai CY, Hsieh MC, Ho YC, Chen GD, Chou D, Ruan T, Lee AS, Wang HH, Chau YP, Peng HY, Lai CH.  GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription. NEUROPHARMACOLOGY. Vol.135:536-546. Jun. 2018. (SCI/SCIE)
21. Ho YC, Lin TB, Hsieh MC, Lai CY, Chou D, Chau YP, Chen GD, Peng HY.  Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression. NEUROPSYCHOPHARMACOLOGY. Vol.43(2):302-312. Jan. 2018. (SCI/SCIE)
22. Hsieh MC, Ho YC, Lai CY, Chou D, Wang HH, Chen GD, Lin TB, Peng HY.  Melatonin impedes Tet1-dependent mGluR5 promoter demethylation to relieve pain. JOURNAL OF PINEAL RESEARCH. Vol.63(4):e12436.-e12436.. Nov. 2017. (SCI/SCIE)
23. Hsieh MC, Ho YC, Lai CY, Wang HH,  Lee AS, Cheng JK, Chau YP, Peng HY.  Bromodomain-containing Protein 4 Activates Voltage-gated Sodium Channel 1.7 Transcription in Dorsal Root Ganglia Neurons to Mediate Thermal Hyperalgesia in Rats. ANESTHESIOLOGY. Vol.127(5):862-877. Nov. 2017. (SCI/SCIE)
24. Lai CY, Hsieh MC, Ho YC, Lee AS, Wang HH, Cheng JK, Chau YP, Peng HY.  Growth Arrest and DNA-damage-inducible Protein 45β-mediated DNA Demethylation of Voltage-dependent T-type Calcium Channel 3.2 Subunit Enhances Neuropathic Allodynia after Nerve Injury in Rats. ANESTHESIOLOGY. Vol.126(6):1077-1095. Jun. 2017. (SCI/SCIE)
25. Hsieh MC, Lai CY, Ho YC, Wang HH,  Jen-Kun Cheng, Chau YP, Peng HY.  Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats. Scientific Reports. Vol.6:37411-37411. Nov. 2016. (SCI/SCIE)
26. Lai CY, Ho YC, Hsieh MC, Wang HH, Cheng JK, Chau YP, Peng HY.  Spinal Fbxo3-Dependent Fbxl2 Ubiquitination of Active Zone Protein RIM1α Mediates Neuropathic Allodynia through CaV2.2 Activation. JOURNAL OF NEUROSCIENCE. Vol.36(37):9722-9738. Sep. 2016. (SCI/SCIE)
27. Lin TB, Hsieh MC, Lai CY, Cheng JK, Wang HH, Chau YP, Chen GD, Peng HY.  Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription. JOURNAL OF PINEAL RESEARCH. Vol.60(3):263-276. Apr. 2016. (SCI/SCIE)
28. Lai CY, Lin TB, Hsieh MC, Chen GD, Peng HY.  SIRPα1-SHP2 Interaction Regulates Complete Freund Adjuvant-Induced Inflammatory Pain via Src-Dependent GluN2B Phosphorylation in Rats. ANESTHESIA AND ANALGESIA. Vol.122(3):871-881. Mar. 2016. (SCI/SCIE)

mchsieh@mmc.edu.tw